OMPK36

OmpK36-mediated Carbapenem resistance attenuates ST258 ...

2 Sep 2019 ... OmpK35ST258 and OmpK36ST258 porin variants do not impact on growth in vitro. a The OmpK35ST258 frame-shift mutation results in a ...

ompk36

Klebsiella pneumoniae Major Porins OmpK35 and OmpK36 Allow ...

4 Nov 2019 ... For constructing the OmpK36 expression vector, the ompK36 gene of K. pneumoniae, together with 170 and 27 nucleotides of upstream and ...

ompk36

Klebsiella pneumoniae Outer Membrane Porins OmpK35 and ...

31 Jan 2011 ... OmpK35 and OmpK36 are the major outer membrane porins of Klebsiella pneumoniae. In this study, a virulent clinical isolate was selected to ...

ompk36

Role of association of OmpK35 and OmpK36 alteration and ...

2 Apr 2019 ... Role of association of OmpK35 and OmpK36 alteration and blaESBL and/or blaAmpC genes in conferring carbapenem resistance among ...

ompk36

6RD3: Crystal structure of the wild type OmpK36 from ... - RCSB PDB

11 Sep 2019 ... Carbapenem-resistance in Klebsiella pneumoniae (KP) sequence type ST258 is mediated by carbapenemases (e.g. KPC-2) and loss or ...

ompk36

Klebsiella pneumoniae Major Porins OmpK35 and OmpK36 Allow ...

4 Nov 2019 ... Klebsiella pneumoniae Major Porins OmpK35 and OmpK36 Allow More Efficient Diffusion of β-Lactams than Their Escherichia coli Homologs ...

ompk36

Prevalence of OmpK35 and OmpK36 porin expression in beta ...

22 Dec 2011 ... Methods: Fifty-two K. pneumoniae isolates were obtained and analyzed for extended-spectrum beta-lactamase and for OmpK35 and OmpK36.

ompk36

Contribution of β-Lactamases and Porin Proteins OmpK35 and ...

25 Nov 2013 ... Contribution of β-Lactamases and Porin Proteins OmpK35 and OmpK36 to Carbapenem Resistance in Clinical Isolates of KPC-2-Producing ...

ompk36

Imipenem-resistance in Klebsiella pneumoniae in Malaysia due to ...

9 Mar 2007 ... Imipenem-resistance in Klebsiella pneumoniae in Malaysia due to loss of OmpK36 outer membrane protein coupled with AmpC ...

ompk36

Study of ompk35 and ompk36 Expression in Carbapenem Resistant ...

Study of ompk35 and ompk36 Expression in Carbapenem Resistant ESBL. Producing Clinical Isolates Of Klebsiella pneumoniae. Amina AM Nour El Din , Reem ...

ompk36

ompK36 - OmpK36 - Klebsiella pneumoniae - ompK36 gene & protein

ompK36. Organism. Klebsiella pneumoniae. Status. Unreviewed-Annotation score: Annotation score:2 out of 5. The annotation score provides a heuristic ...

ompk36

The Mechanism of High-Level Carbapenem Resistance in ...

25 Jul 2013 ... The Mechanism of High-Level Carbapenem Resistance in Klebsiella pneumoniae: Underlying Ompk36-Deficient Strains Represent a Threat of ...

ompk36

Allocation of Klebsiella pneumoniae Bloodstream Isolates into Four ...

29 Jul 2019 ... The OmpK36 porin plays a role in carbapenem resistance and may contribute to bacterial virulence in Klebsiella pneumoniae. This study ...

ompk36

Klebsiella pneumoniae OmpK36

Klebsiella strains expressing OmpK36 are often beta-lactam sensitive even in the ... Klebsiella pneumoniae major porins OmpK35 and OmpK36 allow more ...

ompk36

Evaluation of ompK36 allele groups on clinical characteristics and ...

This study investigated the implications of ompK36 allele groups on clinical and microbiological features of patients with Klebsiella pneumoniae bacteremia.

ompk36

Contribution of acrB upregulation & OmpC/Ompk36 loss over the ...

Contribution of acrB upregulation & OmpC/Ompk36 loss over the presence of bla NDM towards carbapenem resistance development among pathogenic ...

ompk36

Carbapenem and cefoxitin resistance of Klebsiella pneumoniae ...

Carbapenem and cefoxitin resistance of Klebsiella pneumoniae strains associated with porin OmpK36 loss and DHA-1 β-lactamase production. Weifeng ShiI ...

ompk36

Paradoxical effect of Klebsiella pneumoniae OmpK36 porin deficiency

SummaryAim: To evaluate the effect of defined mutations in the major OmpK35 and OmpK36 porins in Klebsiella pneumoniae on the activity of two common ...

ompk36

Protective Efficacy of DNA Vaccines Encoding Outer Membrane ...

3 Nov 2010 ... DNA vaccines consisting of vector pVAX1 expressing either outer membrane protein A or OmpK36 were injected into mice by either the ...

ompk36

(PDF) Klebsiella pneumoniae Outer Membrane Porins OmpK35 and ...

PDF | OmpK35 and OmpK36 are the major outer membrane porins of Klebsiella pneumoniae. In this study, a virulent clinical isolate was selected to study.

ompk36

Contribution of outer membrane protein K36 to antimicrobial ...

7 Mar 2010 ... An OmpK36-deficient mutant (ΔOmpK36) was derived from a virulent clinical isolate by targeted gene insertion. Antimicrobial susceptibility was ...

ompk36

A Porin from Klebsiella pneumoniae: Sequence Homology, Three ...

A recombinant plasmid containing ompK36, the gene coding for the Klebsiella pneumoniae outer membrane protein OmpK36, was constructed by transposon ...

ompk36

Identification of IS1R and IS10R elements inserted into ompk36 ...

11 Apr 2019 ... The outer membrane porin protein ompK36 gene was disrupted by IS elements in two hospital Klebsiella pneumoniae strains resulting in a lack ...

ompk36

Frequency of Ompk35 And Ompk36 in Strains of - scientific journal ...

The aim of our study was expression of OMPK36 and OMPK35 in ESBLs production and non-ESBLs K.pneumoniae. Materials & Methods: Clinical isolates of ...

ompk36

Contribution of OmpK36 to carbapenem susceptibility in KPC ...

Expression of genes encoding KPC, the porins OmpK35 and OmpK36, and the efflux pump AcrAB was examined by real-time RT-PCR. Outer-membrane ...

ompk36

In vivo selection of carbapenem-resistant Klebsiella pneumoniae by ...

1 Dec 2009 ... Insertional inactivation of a major porin gene, ompK36, by IS5 element might play a role in acquiring carbapenem resistance in this strain ...

ompk36

Osmoporin OmpK36 (K. pneumoniae) - Proteopedia, life in 3D

Here, we study osmoporin of the pathogenic Klebsiella pneumoniae (OmpK36), which shares 87% sequence identity with E. coliOmpC in an attempt to establish  ...

ompk36

Host adaptation and convergent evolution increases antibiotic ...

15 Mar 2019 ... OmpK35 and OmpK36 are the major co-regulated outer membrane porins of K. pneumoniae. OmpK36 absence has been related to antibiotic ...

ompk36

OmpK36-mediated Carbapenem resistance attenuates ST258 ...

Title: OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo. Authors: Wong, Joshua L. C.; Romano, Maria; Kerry, Louise  ...

ompk36

Publications - Dr Konstantinos Beis

title = {OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo}, url = {http://dx.doi.org/10.1038/s41467-019-11756-y},

ompk36

Crystal structure and functional characterization of OmpK36, the ...

24 Sep 2019 ... Here, we study osmoporin of the pathogenic Klebsiella pneumoniae (OmpK36), which shares 87% sequence identity with E. coliOmpC in an ...

ompk36

OmpK36-mediated Carbapenem resistance attenuates ST258 in vivo

OmpK36-mediated Carbapenem resistance attenuates ST258 in vivo. Journal: Nature Communications. Published: 2019-09-02.

ompk36

Predictability of phenotype in relation to common β-lactam ...

We demonstrated mutations in ompK36 or absence of OmpK36 in all isolates in which reduced susceptibility to ertapenem (MIC, >1 mg/liter) was evident.

ompk36

Doripenem MICs and ompK36 porin genotypes of sequence type ...

Major ompK36 mutations among KPC-K. pneumoniae strains are important determinants of carbapenem-colistin responses in vitro and in vivo.

ompk36

ompk36

In vivo selection of imipenem-resistant producing extended ...

In addition, KP4 failed to express OmpK36 owing to a point mutation leading to ... of OmpK36 expression in a isolate harbouring extended-spectrum β-lactamse ...

ompk36

BacMet Database

... cyanide 3-chlorophenylhydrazone (CCCP), Benzylkonium Chloride (BAC), Chlorhexidine, Sodium Nitrite (NaNo2), OmpK36. kpnO, 312458450, ADQ89175. 1 ...

ompk36

(PDF) Outbreak Caused by an Ertapenem-Resistant, CTX-M-15 ...

Outbreak Caused by an Ertapenem-Resistant, CTX-M-15-Producing Klebsiella pneumoniae Sequence Type 101 Clone Carrying an OmpK36 Porin Variant ...

ompk36

Zamin Iqbal on Twitter: "".. porin (OmpK35) of Klebsiella ...

17 Jul 2019 ... OmpK36..which provides enhanced antibiotic resistance.."https://twitter.com/ biorxiv_micrbio/status/1019171257366077441 … Zamin Iqbal ...

ompk36

Extensively drug-resistant klebsiella pneumoniae causing ...

30 Jun 2019 ... The porins OmpK35 and OmpK36 were deficient in two carbapenemase- negative carbapenem-resistant strains, suggesting decreased drug ...

ompk36

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